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Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu
《环境科学与工程前沿(英文)》 2019年 第13卷 第4期 doi: 10.1007/s11783-019-1143-2
Specific second-order rate constants were determined for 5-FU and CAP with ozone. Reaction sites were confirmed by kinetics, Fukui analysis, and products. The olefin moiety was the main ozone reaction site for 5-FU and CAP. Carboxylic acids comprised most of the residual TOC for 5-FU. Ozonation removed the toxicity associated with 5-FU and products but not CAP.
关键词: Ozone 5-fluorouracil Capecitabine Hydroxyl radicals Chemotherapy agents Toxicity
Ravikumar KVG, Debayan Ghosh, Mrudula Pulimi, Chandrasekaran Natarajan, Amitava Mukherjee
《环境科学与工程前沿(英文)》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1195-3
关键词: GS-FeNi nanoparticles Tetracycline removal Re-usability Residual toxicity Column studies
Lizhao DAI; Wengang XU; Lei WANG; Shanchang YI; Wen CHEN
《结构与土木工程前沿(英文)》 2022年 第16卷 第3期 页码 388-400 doi: 10.1007/s11709-022-0809-1
关键词: post-tensioned concrete beams strand fracture secondary transfer length residual prestress
Minimal residual disease in solid tumors: an overview
《医学前沿(英文)》 2023年 第17卷 第4期 页码 649-674 doi: 10.1007/s11684-023-1018-6
关键词: MRD solid tumor CTC ctDNA
Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 82-89 doi: 10.1007/s11684-015-0376-0
Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo-fetal developmental toxicity and teratogenicity were studied in pregnant Sprague-Dawley rats after intragastric administration of Metacavir (200, 100, 50, 0 mg/kg body weight) during the first 6–15 days of pregnancy. Slower weight gain was observed in 5 out of 21 rats subjected to a 200 mg/kg dose, as well as 2 out of 20 subjected to a 100 mg/kg dose. Compared with the solvent control group, the calibration weight gain in the 200 mg/kg and 100 mg/kg dosage groups respectively, during first 6–20 pregnant days were significantly different (P<0.01, P<0.05). Significant dose related adverse effects to other reproductive parameters were not seen in F0 and F1, but the number of stillbirths in high dose group showed notably difference compared with the control group (P<0.05), while the litter incidence showed no difference. No Metacavir-associated pathological changes were observed. The present research indicated that at a dose of 200 mg/(kg·d) (i.e., 40 times the effective dose in rats), Metacavir shows some maternal toxicity to SD rats. The embryotoxicity in the 200 mg/kg group encompass decreased fetal body weight, and higher fetal mortality rates, compared with the control group. However, the litter incidence showed no statistical difference. All the treated rats displayed normal bone development, no teratogenicity and without adverse effects on fetal development, thus indicating that below a dose of 200 mg/(kg·d) there is no teratogenic side effects.
关键词: deoxyguanosine analogue Metacavir pregnancy maternal toxicity embryo toxicity teratogenicity
《环境科学与工程前沿(英文)》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1571-2
● Adsorption of PFASs on MPs and its mechanisms are critically reviewed.
关键词: Microplastics Per- and Polyfluoroalkyl substances Adsorption Transport Transformation
《环境科学与工程前沿(英文)》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1501-8
• Oxidation of methotrexate by high-valent metal-oxo species was first explored.
关键词: Anticancer drugs High-valent metal-oxo species Oxidation kinetics Reaction mechanisms Multi-endpoint toxicity
Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse
Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG
《环境科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 89-98 doi: 10.1007/s11783-013-0591-3
关键词: waste foundry sand toxicity bioassay soil microbial activity waste reuse
The formation mechanism and the influence factor of residual stress in machining
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《机械工程前沿(英文)》 2014年 第9卷 第3期 页码 265-269 doi: 10.1007/s11465-014-0311-0
Residual stresses generated in cutting process have important influences on workpiece performance. The paper presents a method of theoretical analysis in order to explicate the formation mechanism of residual stresses in cutting. An important conclusion is drawn that the accumulated plastic strain is the main factor which determines the nature and the magnitude of surface residual stresses in the workpiece. On the basis of the analytical model for residual stress, a series of simulations for residual stress prediction during cutting AISI 1045 steel are implemented in order to obtain the influences of cutting speed, depth of cut and tool edge radius on surface residual stress in the workpiece. And these influences are explained from the perspective of formation mechanism of residual stress in cutting. The conclusions have good applicability and can be used to guide the parameters selection in actual production.
关键词: residual stress analytical model strain plastic cutting parameter
Experiment and optimal design of a collection device for a residual plastic film baler
Qi NIU,Xuegeng CHEN,Chao JI,Jie WU
《农业科学与工程前沿(英文)》 2015年 第2卷 第4期 页码 347-354 doi: 10.15302/J-FASE-2015077
关键词: residual film collection device collection rate of residual film impurity of film package optimization baler
Improved analytical model for residual stress prediction in orthogonal cutting
null
《机械工程前沿(英文)》 2014年 第9卷 第3期 页码 249-256 doi: 10.1007/s11465-014-0310-1
The analytical model of residual stress in orthogonal cutting proposed by Jiann is an important tool for residual stress prediction in orthogonal cutting. In application of the model, a problem of low precision of the surface residual stress prediction is found. By theoretical analysis, several shortages of Jiann’s model are picked out, including: inappropriate boundary conditions, unreasonable calculation method of thermal stress, ignorance of stress constraint and cyclic loading algorithm. These shortages may directly lead to the low precision of the surface residual stress prediction. To eliminate these shortages and make the prediction more accurate, an improved model is proposed. In this model, a new contact boundary condition between tool and workpiece is used to make it in accord with the real cutting process; an improved calculation method of thermal stress is adopted; a stress constraint is added according to the volume-constancy of plastic deformation; and the accumulative effect of the stresses during cyclic loading is considered. At last, an experiment for measuring residual stress in cutting AISI 1045 steel is conducted. Also, Jiann’s model and the improved model are simulated under the same conditions with cutting experiment. The comparisons show that the surface residual stresses predicted by the improved model is closer to the experimental results than the results predicted by Jiann’s model.
关键词: residual stress analytical model orthogonal cutting cutting force cutting temperature
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 doi: 10.15302/J-FASE- 2021390
It has previously been shown that tryptophan, the biosynthesis precursor of Peganum harmala alkaloids, and its derivatives have anti-TMV activity both in vitro and in vivo. Further exploration of this led to the identification of NK0238 as a highly effective agent for the prevention and control of diseases caused by plant viruses, but the existing routes are unsuitable for its large-scale synthesis. This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophan with triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylamine to give NK0238 at up to 94% yield and nearly 97% HPLC purity. In addition, the route was used for the preparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicity tests. NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field experiments. The toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms. The optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies, its excellent activity and safety make NK0238 a promising drug candidate for further development.
Xiaobo REN, Odd M. AKSELSEN, B?rd NYHUS, Zhiliang ZHANG
《结构与土木工程前沿(英文)》 2012年 第6卷 第3期 页码 217-223 doi: 10.1007/s11709-012-0169-3
关键词: residual stress ductile crack growth resistance complete Gurson model eigenstrain method
An improved algorithm for McDowell’s analytical model of residual stress
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《机械工程前沿(英文)》 2014年 第9卷 第2期 页码 150-155 doi: 10.1007/s11465-014-0295-9
The analytical model for two-dimensional elastoplastic rolling/sliding contact proposed by McDowell is an important tool for predicting residual stress in rolling/sliding processes. In application of the model, a problem of low predicting precision near the surface layer of the component is found. According to the volume-constancy of plastic deformation, an improved algorithm for McDowell’s model is proposed in order to improve its predicting accuracy of the surface residual stress. In the algorithm, a relationship between three normal stresses perpendicular to each other at any point within the component is derived, and the relationship is applied to McDowell’s model. Meanwhile, an unnecessary hypothesis proposed by McDowell can be eliminated to make the model more reasonable. The simulation results show that the surface residual stress predicted by modified method is much closer to the FEM results than the results predicted by McDowell’s model under the same simulation conditions.
关键词: residual stress McDowell’s model volume-constancy of plastic deformation FEM elastoplastic rolling/sliding contact
《环境科学与工程前沿(英文)》 2022年 第16卷 第5期 doi: 10.1007/s11783-021-1493-4
• A two-compartment model is able to quantify the effect of nano-TiO2 on Pb toxicity.
关键词: Algae C. dubia Lead Nano-TiO2 Synergistic toxicity Two-compartment toxicokinetic-toxicodynamic model
标题 作者 时间 类型 操作
fluorouracil anticancer drug and its prodrug capecitabine: Reaction kinetics, oxidation mechanisms, and residualtoxicity
Siyu Chen, Lee Blaney, Ping Chen, Shanshan Deng, Mamatha Hopanna, Yixiang Bao, Gang Yu
期刊论文
In situ formation of bimetallic FeNi nanoparticles on sand through green technology: Application for tetracycline removal
Ravikumar KVG, Debayan Ghosh, Mrudula Pulimi, Chandrasekaran Natarajan, Amitava Mukherjee
期刊论文
Secondary transfer length and residual prestress of fractured strand in post-tensioned concrete beams
Lizhao DAI; Wengang XU; Lei WANG; Shanchang YI; Wen CHEN
期刊论文
Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats
null
期刊论文
Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic
期刊论文
Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate
期刊论文
Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse
Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG
期刊论文
Experiment and optimal design of a collection device for a residual plastic film baler
Qi NIU,Xuegeng CHEN,Chao JI,Jie WU
期刊论文
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
期刊论文
Influence of welding residual stresses on the ductile crack growth resistance of circumferentially cracked
Xiaobo REN, Odd M. AKSELSEN, B?rd NYHUS, Zhiliang ZHANG
期刊论文